Kelvin Wong, Khai Voon and Ahmad Mahfuz, Gazali and Normaiza, Zamri and Kamal, Rullah and Mohd Fadhlizil Fasihi, Mohd Aluwi (2022) A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer. Journal of Computational Biophysics and Chemistry. pp. 1-16. ISSN 2737-4173. (Published)
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Abstract
Breast cancer, which has been one of the most frequently diagnosed cancers worldwide for decades, continues to defy treatment. While researching a remedy to this problem, it was discovered that mTOR has a strong association with breast cancer. Uncontrolled activation of mTOR is shown in a variety of different cancer, making it a critical target for cancer treatment. Inhibition of the mTOR protein kinase can cause autophagic cell death. It is known that covalent inhibitors have become a prominent issue in drug discovery, with covalent inhibitors focusing on α,β-unsaturated carbonyl molecules. Structural modifications to α,β-unsaturated carbonyl may be one of the finest avenues for developing the best breast cancer medication. This review article discusses recent research on natural and synthetic α,β-unsaturated carbonyls and their anti-cancer properties targeting on mTOR, with SAR to showcase the efficacy of synthetic natural products compared to parental compounds using both biological assays and in silico studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | α,β-unsaturated carbonyl, breast cancer, mTOR pathway, molecular docking, SAR |
| Subjects: | R Medicine > R Medicine (General) T Technology > TP Chemical technology |
| Faculty/Division: | Centre of Excellence: Bio-Aromatic Research Center of Excellence Faculty of Industrial Sciences And Technology |
| Depositing User: | Noorul Farina Arifin |
| Date Deposited: | 17 Jun 2022 08:36 |
| Last Modified: | 17 Jun 2022 08:36 |
| URI: | http://umpir.ump.edu.my/id/eprint/34459 |
| Download Statistic: | View Download Statistics |
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