Cranial morphology associated with syndromic graniosynostosis: A potential detection of abnormality in patient’s cranial growth using angular statistics

Nur Syahirah, Zulkipli and Siti Zanariah, Satari and Norli Anida, Abdullah and Wan Nur Syahidah, Wan Yusoff and Abdul Ghapor, Hussin (2022) Cranial morphology associated with syndromic graniosynostosis: A potential detection of abnormality in patient’s cranial growth using angular statistics. The Cleft Palate-Craniofacial Journal. pp. 1-10. ISSN 1055-6656 (Printed) 1545-1569(online). (Published)

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Abstract

Introduction: Apert, Crouzon, and Pfeiffer syndromes are common genetic syndromes related to syndromic craniosynostosis (SC), whereby it is a congenital defect that occurs when the cranial growth is distorted. Identifying cranial angles associated with these 3 syndromes may assist the surgical team to focus on a specific cranial part during the intervention planning, thus optimizing surgical outcomes and reducing potential morbidity. Objective: The aim of this study is to identify the cranial angles, which are associated with Apert, Crouzon, and Pfeiffer syndromes. Methods: The cranial computed tomography scan images of 17 patients with SC and 22 control groups aged 0 to 12 years who were treated in the University Malaya Medical Centre were obtained, while 12 angular measurements were attained using the Mimics software. The angular data were then divided into 2 groups (patients aged 0 to 24 months and >24 months). This work proposes a 95% confidence interval (CI) for angular mean to detect the abnormality in patient’s cranial growth for the SC syndromes. Results: The 95% CI of angular mean for the control group was calculated and used as an indicator to confirm the abnormality in patient’s cranial growth that is associated with the 3 syndromes. The results showed that there are different cranial angles associated with these 3 syndromes. Conclusions: All cranial angles of the patients with these syndromes lie outside the 95% CI of angular mean of control group, indicating the reliability of the proposed CI in the identification of abnormality in the patient’s cranial growth.

Item Type: Article
Uncontrolled Keywords: craniofacial morphology, Apert syndrome, craniofacial growth, syndromic craniosynostosis
Subjects: Q Science > QA Mathematics
Faculty/Division: Institute of Postgraduate Studies
Center for Mathematical Science
Depositing User: Miss. Ratna Wilis Haryati Mustapa
Date Deposited: 17 Oct 2022 09:21
Last Modified: 17 Oct 2022 09:21
URI: http://umpir.ump.edu.my/id/eprint/35467
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