Yuan, Bo and Haug, Line Småstuen and Tay, Joo Hui and Padilla-Sanchez, Juan Antonio and Papadopoulou, Eleni and de Wit, Cynthia A. (2022) Dietary Intake Contributed the Most to Chlorinated Paraffin Body Burden in a Norwegian Cohort. Environmental Science & Technology, 56. pp. 17080-17089. ISSN 1520-5851. (Published)
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Abstract
Determining the major human exposure pathways is a prerequisite for the development of effective management strategies for environmental pollutants such as chlorinated paraffins (CPs). As a first step, the internal and external exposure to CPs were quantified for a well-defined human cohort. CPs in participants' plasma and diet samples were analyzed in the present study, and previous results on paired air, dust, and hand wipe samples were used for the total exposure assessment. Both one compartment pharmacokinetic modeling and forensic fingerprinting indicate that dietary intake contributed the most to body burden of CPs in this cohort, contributing a median of 60-88% of the total daily intakes. The contribution from dust ingestion and dermal exposure was greater for the intake of long-chain CPs (LCCPs) than short-chain CPs (SCCPs), while the contribution from inhalation was greater for the intake of SCCPs than medium-chain CPs (MCCPs) and LCCPs. Significantly higher concentrations of SCCPs and MCCPs were observed in diets containing butter and eggs, respectively (p < 0.05). Additionally, other exposure sources were correlated to plasma levels of CPs, including residence construction parameters such as the construction year (p < 0.05). This human exposure to CPs is not a local case. From a global perspective, there are major knowledge gaps in biomonitoring and exposure data for CPs from regions other than China and European countries.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | human exposure, cohort study, chlorinated paraffins, plasma, external exposure pathways, dietary intake |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Faculty/Division: | Faculty of Industrial Sciences And Technology |
| Depositing User: | Dr. Joo Hui Tay |
| Date Deposited: | 28 Dec 2022 08:02 |
| Last Modified: | 28 Dec 2022 08:02 |
| URI: | http://umpir.ump.edu.my/id/eprint/35912 |
| Download Statistic: | View Download Statistics |
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