Delivery of bioencapsulated proteins

Nor Hasmaliana, Abdul Manas and Dayang Norulfairuz, Abang Zaidel and Nur Izyan, Wan Azelee and Siti Fatimah Zaharah, Mohd Fuzi and Aizi Nor Mazila, Ramli and Shalyda, Md Shaarani and Rosli, Md. Illias and Norsuhada, Abdul Karim (2023) Delivery of bioencapsulated proteins. In: Smart Nanomaterials for Bioencapsulation. Elsevier, pp. 63-75. ISBN 9780323912297 (Unpublished)

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Proteins and peptides have been used in pharmaceutical, nutraceutical, and food applications for their therapeutic and nutritional properties. However, administration of these molecules to the human body is challenging due to their low stability, low bioavailability, high biodegradability, immunogenicity, and inefficient permeability. These molecules require a tailored delivery system to ensure bioavailability and efficient maintenance to target location. Nanotechnology has emerged as an ideal platform in drug delivery as it provides a versatile system with excellent biocompatibility. This chapter discusses various nanomaterials that have been explored, particularly organic, inorganic, protein, and hybrid nanomaterials which are biocompatible for administration to human body. Challenges for the development of protein in nanomaterials are outlined and strategies for the nanoencapsulation in these nano-vehicles are discussed that aim for preservation of bioactivity, high protein loading, structural stability, permeability, and control release besides being easy for synthesis and cost-effective.

Item Type: Book Chapter
Uncontrolled Keywords: Drug delivery system, Nanotechnology, Bioencapsulation, Controlled release, Proteins and peptides, Therapeutic proteins, Nanoencapsulation
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
R Medicine > RS Pharmacy and materia medica
T Technology > T Technology (General)
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Administrator admin
Date Deposited: 24 May 2023 07:46
Last Modified: 16 Aug 2023 23:59
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