Applications of nanomaterials for biosensor fabrication based on redox enzyme and protein: A short review

Kader, Md. Ashraful and Kafi, A. K. M. and Nina Suhaity, Azmi (2023) Applications of nanomaterials for biosensor fabrication based on redox enzyme and protein: A short review. Current Science and Technology (CST), 2 (2). pp. 20-28. ISSN 2785-8804. (Published)

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Redox enzyme and protein modified biosensors are commercially triumphant bioelectronic devices used in the point-of-care analysis. The use of nanotechnology derived nanomaterials during enzyme immobilization creates a synergistic effect by integrating enzyme’s recognition and catalytic properties with the electronic properties of nanomaterials. This synergy improves the biosensor’s sensitivity, conductivity stability, surface-to-volume ratio, selectivity, detection limit and other analytical features. This critical review focuses on the redox enzymes and proteins most frequently used in glucose and hydrogen peroxide sensing, such as horseradish peroxidase (HRP), glucose oxidase (GOx), hemoglobin (HB), and cytochrome C (Cyt c). Besides, we evaluate the state of art of this approach, selection of nanomaterials, preparation and immobilization mechanisms, their role and sensing applications. Besides advantages, the discussions have discussed on the pressing challenges of developing these sensors. This review will guide the research community to develop rational and highly efficient nanomaterial immobilized biosensors.

Item Type: Article
Uncontrolled Keywords: Biosensor; Horseradish peroxidase; Glucose oxidase; Hemoglobin; Cytochrome C; Nanomaterials
Subjects: Q Science > QD Chemistry
T Technology > TP Chemical technology
Faculty/Division: Faculty of Industrial Sciences And Technology
Institute of Postgraduate Studies
Depositing User: Mrs Norsaini Abdul Samat
Date Deposited: 10 Aug 2023 07:11
Last Modified: 10 Aug 2023 07:11
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