Ezhilnavaroji, Jeroish Zachariah and Bhuvaneshwari, K. S. and Futane, Abhishek and Fahmi, Samsuri and Narayanamurthy, Vigneswaran (2023) Design, optimization, fabrication and analysis of Cu microheater for loop-mediated isothermal amplification (LAMP) applications. Materials Today Communications, 36 (106663). ISSN 2352-4928. (Published)
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Abstract
A paper presents the design, fabrication, and thermal evaluation of a printed circuit board (PCB) based copper (Cu) microheater that can be integrated with microfluidic chips to initiate the loop-mediated isothermal amplification (LAMP). A series of 3D finite element electro-thermal simulations were carried out to analyze the thermal uniformity and power consumption of the micro heater. The optimal design was fabricated using the etching technique and analyzed with a heat spreader to enhance thermal uniformity. The simulation results of the microheater reveal that the meander configuration outperforms other designs. In addition, the microheater with a heat spreader has a thermal difference of only < 5 ℃ when compared with ∼10 ℃ in a microheater without a heat spreader. The developed microheater has a long shelf life and can be used to handle wet biological samples when encapsulated with polyethylene terephthalate (PET). The paper microfluidic chip on the glass substrate has a temperature difference of only 0.5 ℃. The low-cost microheater integrated microfluidic chips has the great potential to develop inexpensive home-based diagnostic kits and trigger the access of diagnostic kits in underdeveloped countries to reduce the spread of infection and initiate treatment plans.
| Item Type: | Article |
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| Additional Information: | indexed by Scopus |
| Uncontrolled Keywords: | PCB; Microfluidic chip; Microheater; LAM |
| Subjects: | T Technology > T Technology (General) T Technology > TK Electrical engineering. Electronics Nuclear engineering |
| Faculty/Division: | Institute of Postgraduate Studies College of Engineering |
| Depositing User: | Miss Amelia Binti Hasan |
| Date Deposited: | 14 Nov 2023 06:12 |
| Last Modified: | 14 Nov 2023 06:12 |
| URI: | http://umpir.ump.edu.my/id/eprint/39298 |
| Download Statistic: | View Download Statistics |
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