Kauthar, Mohd Daud and Ananda, Ridho and Suhaila, Zainudin and Chan, Weng Howe and Moorthy, Kohbalan and Nurul Izrin, Md Saleh (2023) Optimizing the production of valuable metabolites using a hybrid of constraint-based model and machine learning algorithms : A review. International Journal of Advanced Computer Science and Applications, 14 (10). pp. 1091-1105. ISSN 2158-107X. (Published)
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Abstract
The advances in genome sequencing and metabolic engineering have allowed the reengineering of the cellular function of an organism. Furthermore, given the abundance of omics data, data collection has increased considerably, thus shifting the perspective of molecular biology. Therefore, researchers have recently used artificial intelligence and machine learning tools to simulate and improve the reconstruction and analysis by identifying meaningful features from the large multi-omics dataset. This review paper summarizes research on the hybrid of constraint-based models and machine learning algorithms in optimizing valuable metabolites. The research articles published between 2020 and 2023 on machine learning and constraintbased modeling have been collected, synthesized, and analyzed. The articles are obtained from the Web of Science and Scopus databases using the keywords: “Machine learning”, “flux balance analysis”, and “metabolic engineering”. At the end of the search, this review contained 13 records. This review paper aims to provide current trends and approaches in in silico metabolic engineering while providing research directions by highlighting the research gaps. In addition, we have discussed the methodology for integrating machine learning and constraint-based modeling approaches.
| Item Type: | Article |
|---|---|
| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Flux balance analysis; Genome-scale metabolic model; Machine learning; Metabolic engineering |
| Subjects: | Q Science > QA Mathematics > QA75 Electronic computers. Computer science Q Science > QA Mathematics > QA76 Computer software T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General) |
| Faculty/Division: | Faculty of Computing |
| Depositing User: | Mr Muhamad Firdaus Janih@Jaini |
| Date Deposited: | 30 Apr 2024 06:42 |
| Last Modified: | 30 Apr 2024 06:42 |
| URI: | http://umpir.ump.edu.my/id/eprint/40654 |
| Download Statistic: | View Download Statistics |
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