Plasma haptoglobin as a potential biomarker for coronary artery disease in young hypertensive adults

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Abstract

Uncontrolled hypertension is one of the recognized risk factors for coronary artery disease (CAD) in young adults, commonly underestimated owing to the young age. A novel biomarker to improve CAD risk assessment and hypertension management should be identified for this cohort. Thus, we had conducted a study to investigate plasma concentration and the role of haptoglobin in young hypertensive adults in the establishment of premature acute myocardial infarction (AMI). MATERIALS AND METHODS: A total of 120 male adults aged between 18 to 45 years enrolled into this cross-sectional study, divided into control, hypertensive, and acute myocardial infarction (AMI) groups. Blood samples were collected from all subjects, plasma concentrations of haptoglobin measured using enzyme-linked immunosorbent assays, and other CAD risk factors including high sensitivity C-reactive protein (hs-CRP) levels were analyzed. RESULTS: Plasma concentration of haptoglobin in the AMI group was the highest compared to hypertensive and control group (290.63±99.90 vs. 208.47±112.93 vs. 170.02±108.11 ng/ml, p<0.006). There was a significant association between AMI and plasma haptoglobin concentration in hypertensive subjects independent of other known CAD risk factors (OR: 0.985, 95% CI 0.973-0.997, p=0.017). There was positive correlation between plasma haptoglobin and hs-CRP (r=0.0370, p<0.001). CONCLUSION: Plasma haptoglobin is a potential biomarker to identify young hypertensive adults who are at risk of developing CAD.

Item Type:	Article
Additional Information:	Indexed by Scopus
Uncontrolled Keywords:	Biomarker; Coronary artery disease; Haptoglobin; Hypertension; Young adults
Subjects:	H Social Sciences > HD Industries. Land use. Labor Q Science > Q Science (General) T Technology > T Technology (General)
Faculty/Division:	Faculty of Industrial Sciences And Technology
Depositing User:	Mr Muhamad Firdaus Janih@Jaini
Date Deposited:	01 Jul 2024 01:04
Last Modified:	01 Jul 2024 01:04
URI:	http://umpir.ump.edu.my/id/eprint/41279
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