Candida albicans skin infection in diabetic patients: An updated review of pathogenesis and management

Sakina, Shahabudin and Nina Suhaity, Azmi and Mohd Nizam, Lani and Mukhtar, Muhammad and Hossain, Md. Sanower (2024) Candida albicans skin infection in diabetic patients: An updated review of pathogenesis and management. Mycoses, 67 (6). pp. 1-21. ISSN 0933-7407. (Published)

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Abstract

Candida species, commensal residents of human skin, are recognized as the cause of cutaneous candidiasis across various body surfaces. Individuals with weakened immune systems, particularly those with immunosuppressive conditions, are significantly more susceptible to this infection. Diabetes mellitus, a major metabolic disorder, has emerged as a critical factor inducing immunosuppression, thereby facilitating Candida colonization and subsequent skin infections. This comprehensive review examines the prevalence of different types of Candida albicans-induced cutaneous candidiasis in diabetic patients. It explores the underlying mechanisms of pathogenicity and offers insights into recommended preventive measures and treatment strategies. Diabetes notably increases vulnerability to oral and oesophageal candidiasis. Additionally, it can precipitate vulvovaginal candidiasis in females, Candida balanitis in males, and diaper candidiasis in young children with diabetes. Diabetic individuals may also experience candidal infections on their nails, hands and feet. Notably, diabetes appears to be a risk factor for intertrigo syndrome in obese individuals and periodontal disorders in denture wearers. In conclusion, the intricate relationship between diabetes and cutaneous candidiasis necessitates a comprehensive understanding to strategize effective management planning. Further investigation and interdisciplinary collaborative efforts are crucial to address this multifaceted challenge and uncover novel approaches for the treatment, management and prevention of both health conditions, including the development of safer and more effective antifungal agents.

Item Type:	Article
Uncontrolled Keywords:	Antifungal treatment; Candida albicans; Cutaneous candidiasis; Diabetes mellitus; Pathogenicity; Prevention
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history R Medicine > RC Internal medicine
Faculty/Division:	Faculty of Industrial Sciences And Technology Institute of Postgraduate Studies Centre for Sustainability of Mineral & Resource Recovery Technology (SMARRT)
Depositing User:	Mrs Norsaini Abdul Samat
Date Deposited:	19 Jun 2024 08:34
Last Modified:	19 Jun 2024 08:34
URI:	http://umpir.ump.edu.my/id/eprint/41606
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