Aina Najwa, Nadzri and Nik Abdullah, Nik Mohamed and Payne, Stephen J. and Mohd Jamil, Mohamed Mokhtarudin (2024) Poroelastic modelling of brain tissue swelling and decompressive craniectomy treatment in ischaemic stroke. Computer Methods in Biomechanics and Biomedical Engineering. pp. 1-12. ISSN 1025-5842. (In Press / Online First) (In Press / Online First)
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Abstract
Brain oedema or tissue swelling that develops after ischaemic stroke can cause detrimental effects, including brain herniation and increased intracranial pressure (ICP). These effects can be reduced by performing a decompressive craniectomy (DC) operation, in which a portion of the skull is removed to allow swollen brain tissue to expand outside the skull. In this study, a poroelastic model is used to investigate the effect of brain ischaemic infarct size and location on the severity of brain tissue swelling. Furthermore, the model will also be used to evaluate the effectiveness of DC surgery as a treatment for brain tissue swelling after ischaemia. The poroelastic model consists of two equations: one describing the elasticity of the brain tissue and the other describing the changes in the interstitial tissue pressure. The model is applied on an idealized brain geometry, and it is found that infarcts with radius larger than approximately 14 mm and located near the lateral ventricle produce worse brain midline shift, measured through lateral ventricle compression. Furthermore, the model is also able to show the positive effect of DC treatment in reducing the brain midline shift by allowing part of the brain tissue to expand through the skull opening. However, the model does not show a decrease in the interstitial pressure during DC treatment. Further improvement and validation could enhance the capability of the proposed poroelastic model in predicting the occurrence of brain tissue swelling and DC treatment post ischaemia.
| Item Type: | Article |
|---|---|
| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Brain tissue swelling; Decompressive craniectomy; Ischaemic stroke; Poroelastic model |
| Subjects: | Q Science > QA Mathematics > QA75 Electronic computers. Computer science T Technology > TS Manufactures |
| Faculty/Division: | Institute of Postgraduate Studies Faculty of Manufacturing and Mechatronic Engineering Technology |
| Depositing User: | Mrs Norsaini Abdul Samat |
| Date Deposited: | 17 Jul 2024 04:40 |
| Last Modified: | 17 Jul 2024 04:40 |
| URI: | http://umpir.ump.edu.my/id/eprint/41979 |
| Download Statistic: | View Download Statistics |
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