Hazrulrizawati, Abd Hamid and Roziasyahira, Mutazah and Izzah Hayati, Yahya and Zeyohannes, Senait Sileshi (2021) Antioxidant and antimicrobial screening of isolated alkaloids from tinospora crispa. In: Materials Science Forum. 2nd Postgraduate Symposium on Industrial Science and Technology, SISTEC 2020 , 26 - 27 August 2020 , Virtual, Online. pp. 163-168., 1025. ISSN 0255-5476 ISBN 978-303573757-8 (Published)
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Abstract
The antioxidant capacity by DPPH radical scavenging and antimicrobial activity by disk diffusion and broth microdilution method of nine isolated alkaloids from T. crispa were evaluated. All isolated alkaloids had been divided into three groups which were aporphine alkaloids, N-formylannonaine (1), N-formylnornuciferine (2), magnoflorine (9), oxoaporphine alkaloids, lysicamine (3) and liriodenine (4); and protoberberine alkaloids, columbamine(6), dihydrodiscretamine (7) and 4,13-dihydroxy-2,8,9-trimethoxydibenzo [a,g]quinolizinium (8). Protoberberine alkaloids showed (IC50 > 500-800 μg/mL) radical scavenging activity while oxaporphine alkaloids inhibited the growth of the Gram-positive bacteria, Staphylococcus aureus (+) and Enterococcus faecalis (+).The antioxidant and antimicrobial properties of different compounds support documented traditional use of T. crispa in wound healing and treatment of rheumatic, diarrhoea, ulcers, itches and wounds. Results of the present biological activity investigation further points to the potential of this plant species as a good source of natural antioxidant and preservative in food industry.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Alkaloids; Antimicrobial; Tinospora crispa; Antioxidant; DPPH radical scavenging activity |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Faculty/Division: | Faculty of Industrial Sciences And Technology Institute of Postgraduate Studies |
| Depositing User: | Dr. Hazrulrizawati Abd Hamid |
| Date Deposited: | 01 Oct 2024 06:22 |
| Last Modified: | 01 Oct 2024 06:22 |
| URI: | http://umpir.ump.edu.my/id/eprint/42679 |
| Download Statistic: | View Download Statistics |
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