3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231

Akhtar, Muhammad Nadeem and Nadiah, Abu and Wan, Yong Ho and Swee, Keong Yeap and Noorjahan Banu, Alitheen (2013) 3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231. Molecules, 18 (9). pp. 10367-10377. ISSN 1420-3049 (print); 1420-3049 (online). (Published)

PDF (fist-2013-nadeem-art3-Bromo-1-Hydroxy) fist-2013-nadeem-art3-Bromo-1-Hydroxy.pdf - Published Version Restricted to Repository staff only Download (836kB) | Request a copy

Abstract

Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinones are an interesting class of molecules that display a wide spectrum of biological applications, including anticancer properties. Cellular inhibition was tested through a MTT assay, double acridine orange/propidium iodide staining and FACS cell cycle analysis. Inhibition of migration was tested by the wound healing method, and migration through a Boyden chamber. BHAQ was cytotoxic towards both cell lines in a dose dependent and possibly cell-dependent manner. Additionally, BHAQ also inhibited the migration of the highly metastatic MDA-MB231 cell line.

Item Type:	Article
Additional Information:	Indexed in ISI, Scopus. IF: 2.428
Uncontrolled Keywords:	Anthraquinone; BHAQ; Cytotoxic; MDA-MB231; MCF-7; Migration
Subjects:	Q Science > QD Chemistry
Faculty/Division:	Faculty of Industrial Sciences And Technology
Depositing User:	Noorul Farina Arifin
Date Deposited:	31 Mar 2014 07:40
Last Modified:	18 Apr 2018 04:15
URI:	http://umpir.ump.edu.my/id/eprint/5212
Download Statistic:	View Download Statistics

Actions (login required)

View Item