Antioxidant and Lipoxygenase Inhibiting New Iridoid Glucosides from Caryopteris Odorata

Akhtar, Muhammad Nadeem and Shahzadi, Tayyab and Abbasi, Muhammad Athar and Ur-Rehman, Aziz and Riaz, Tauheed and Khan, Khalid Mohammed and Mohd Ashraf, Ahmad and Afzal, Iftikhar and Ajaib, Muhammad (2013) Antioxidant and Lipoxygenase Inhibiting New Iridoid Glucosides from Caryopteris Odorata. Natural Product Research: Formerly Natural Product Letters, 27 (4-5). pp. 302-313. ISSN 1478-6419 (print); 1478-6427 (online). (Published)

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DOI/Official URL: http://dx.doi.org/10.1080/14786419.2012.668692

Abstract

The phytochemical investigation of the ethylacetate-soluble fraction of Caryopteris odorata (Ham. ex Roxb.) led to the isolation of four new iridoid glucosides (1–4): 8-O-trans-cinnamoyl caryoptoside (1), 8-O-trans-cinnamoyl shanzhiside methylester (2), 8-O-trans-cinnamoyl mussaenoside (3) and 8-O-cafeoyl massenoside (4). The structures of these compounds were determined by FAB-MS, IR, 1D and 2D-NMR spectroscopy and by comparing with the published data of the closely related compounds. The antioxidant potential of the isolated iridoids (1–4) was evaluated relative to conventionally used standards and these molecules exhibited good antioxidant potential. Moreover, their inhibitory potential was also screened against three enzymes, namely acetyl cholinesterase, butyrylcholinesterase and lipoxygenase. These iridoid glucosides were found to be inactive against acetyl and butyrylcholinesterases but active against lipoxygenase.

Item Type:	Article
Additional Information:	Indexed in ISI. IF: 1.031
Uncontrolled Keywords:	Caryopteris odorata (Ham. ex Roxb.); Iridoid glucosides; Antioxidant potential; Acetyl cholinesterase; Butyrylcholinesterase; Lipoxygenase
Subjects:	Q Science > QD Chemistry
Faculty/Division:	Faculty of Industrial Sciences And Technology
Depositing User:	Noorul Farina Arifin
Date Deposited:	31 Mar 2014 08:21
Last Modified:	06 Feb 2018 07:40
URI:	http://umpir.ump.edu.my/id/eprint/5215
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