Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering

Farah Hanani, Zulkifli and Jahir Hussain, Fathima Shahitha and M. M., Yusoff and Mohammad Syaiful Bahari, Abdull Rasad (2014) Nanostructured Materials From Hydroxyethyl Cellulose For Skin Tissue Engineering. Carbohydrate Polymers, 114. pp. 238-245. ISSN 0144-8617. (Published)

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Abstract

In this study, a novel fibrous membrane of hydroxyethyl cellulose (HEC)/poly(vinyl alcohol) blend was successfully fabricated by electrospinning technique and characterized. The concentration of HEC (5%) with PVA (15%) was optimized, blended in different ratios (30–50%) and electrospun to get smooth nanofibers. Nanofibrous membranes were made water insoluble by chemically cross-linking by glutaraldehyde and used as scaffolds for the skin tissue engineering. The microstructure, morphology, mechanical and thermal properties of the blended HEC/PVA nanofibrous scaffolds were characterized by scanning electron microscope, Fourier transform infrared spectroscopy, differential scanning colorimetry, universal testing machine and thermogravimetric analysis. Cytotoxicity studies on these nanofibrous scaffolds were carried out using human melanoma cells by the MTT assays. The cells were able to attach and spread in the nanofibrous scaffolds as shown by the SEM images. These preliminary results show that these nanofibrous scaffolds that supports cell adhesion and proliferation is promising for skin tissue engineering.

Item Type:	Article
Uncontrolled Keywords:	Electrospinning; Hydroxyethyl cellulose; Nanofibrous scaffolds; Skin tissue engineering
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Faculty/Division:	Faculty of Industrial Sciences And Technology
Depositing User:	Mrs. Neng Sury Sulaiman
Date Deposited:	27 Oct 2014 06:36
Last Modified:	26 Jul 2018 06:55
URI:	http://umpir.ump.edu.my/id/eprint/6597
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