Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System

Noor Ashila, Ramle and Syarifah, Abd Rahim and El-Hadad, Omar and Nornizar, Anuar (2015) Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System. Advanced Materials Research, 1113. pp. 434-439. ISSN 1022-6680 (print), 1662-8985 (online). (Published)


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Solubility of carbamazepine co-crystal produced from cooling co-crystallization process with succinic acid as a co-crystal former is investigated in this study. Two techniques are used to determine the solubility of the co-crystal which is gravimetric and HPLC.The solubility experiment in ethanol solvent system were conducted at 6 different temperatures (25, 30, 35, 40, 45 and 50°c) while for succinic acid solution system were conducted at 5 different concentration ratio. Both of the system are equilibrated for 72 hours. Result from the experiment has shown that the solubility of co-crystal is depending on temperature. As the temperature increase, the solubility of co-crystal also increased, this situation meets the Second Law of Thermodynamic which heat facilitates the dissolution process by providing more energy to the system.

Item Type: Article
Additional Information: International Conference On Global Sustainability And Chemical Engineering (ICGSCE 2014), 20-22 August 2014, Kuala Lumpur
Uncontrolled Keywords: Solubility; Pharmaceutical co-crystal; Carbamazepine
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Chemical & Natural Resources Engineering
Depositing User: Mrs. Neng Sury Sulaiman
Date Deposited: 18 Sep 2014 06:57
Last Modified: 29 Sep 2017 07:57
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