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Solid Phase Transformation and Stability of Carbamazepine-adipic Acid Co-Crystal

Mohd Rohaizam, Mohd Sidek (2012) Solid Phase Transformation and Stability of Carbamazepine-adipic Acid Co-Crystal. Faculty of Chemical and Natural Resources Engineering, Universiti Malaysia Pahang.

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Abstract

Co-crystal is a mixed crystal or crystal that contains two or more different molecules. In this study, the solid phase transformation of CBZ-AA co-crystal and solubility of carbamazepine (CBZ) and adipic acid (AA) is examined. In this dissertation, the solubility of CBZ and AA via HPLC and gravimetric methods are reported. On the other hand, the study of solid phase transformation is planned to proceed via slurry co-crystallization method. The result shows the solubility of CBZ and AA via gravimetric and HPLC method is increased as the temperature increased from 25 ˚C to 50 ˚C. TGA analysis shows the weight changed of CBZ is 96.21 % at decomposed temperature of 250 ˚C and 94.47 % for AA at 220 ˚C decomposed temperature. The wavenumbers corresponding to CBZ and AA is obtained from FTIR analysis. Due to time limitation, the phase transformation of CBZ-AA co-crystal is suggested to be continued by another student in the future.

Item Type: Undergraduates Project Papers
Additional Information: Project paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang - 2012
Uncontrolled Keywords: Crystallization Adipic acid
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Chemical & Natural Resources Engineering
Depositing User: Ms Suriati Mohd Adam
Date Deposited: 10 Nov 2014 01:09
Last Modified: 03 Mar 2015 09:34
URI: http://umpir.ump.edu.my/id/eprint/7117
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