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Solid phase transformation and stability of carbamazepine-saccharin co-crystal

Nazrul Shafeeq, Shahadan (2012) Solid phase transformation and stability of carbamazepine-saccharin co-crystal. Faculty of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang.


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Formulation of drug products is a multidisciplinary field, with pharmaceutical materials science being a fundamental branch that continuously provides important insights, theories, and technologies to formulation sciences. The recent advances in this area have brought this research possibility to produce pharmaceutical materials by crystallization design. This research is conducted to determine the character by both physical and chemical properties beside to determine the solubility of Carbamazepine and Saccharin. It is started by determine the co-crystal solubility of Carbamazepine and. Saccharin by applying the different concentration and temperature of Carbamazepine and Saccharin solution by following gravimetric method. It is proceed by determine the characterization of solution by screening using FTIIR, TGA and DSC to get morphology, melting point, weight loss and wavelength. The final discussion after result finding, it can be concluding that concentration and temperature are the main factor to control the solubility of Carbamazepine and Saccharin co-crystal. By using the solubility that was obtained from the gravimetric method, the characterization process of both Carbamazepine and Saccharin are also conclude by their own properties. As an additional conclusion, solid state form of active pharmaceutical ingredients (APIs), cocrystals not only offer a tool for tailoring physicochemical properties, but also create new opportunities for the research-based pharmaceutical companies to address intellectual property (IP) protection issues.

Item Type: Undergraduates Project Papers
Additional Information: Project paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang - 2012
Uncontrolled Keywords: Crystallization Saccharin
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Chemical & Natural Resources Engineering
Depositing User: nurudin nasir
Date Deposited: 10 Nov 2014 01:09
Last Modified: 03 Mar 2015 09:34
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