Preparation of Mesoporous Silica-Supported Chiral Amino Alcohols for the Enantioselective Addition of Diethylzinc to Aldehyde and Asymmetric Transfer Hydrogenation to Ketones

Sarkar, Shaheen M. and Md. Eaqub, Ali and Lutfor, M. R. and M. M., Yusoff Preparation of Mesoporous Silica-Supported Chiral Amino Alcohols for the Enantioselective Addition of Diethylzinc to Aldehyde and Asymmetric Transfer Hydrogenation to Ketones. Journal of Nanomaterials (Articl). pp. 1-6. ISSN 1687-4110 (print); 1687-4129 (online). (Published)

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Abstract

Optically active (−)-ephedrine, (−)-norephedrine, and (−)-prolinol were immobilized onto cubicmesoporousMCM-48 silica. The immobilized amino alcohols served as a heterogeneous chiral catalyst for the asymmetric addition of diethylzinc to aldehydes and transfer hydrogenation to ketones. The developed catalytic process yielded optically enriches secondary aromatic alcohols with 92–99% conversion and 70–82% enantioselectivity.

Item Type: Article
Subjects: Q Science > QD Chemistry
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Dr. Md Shaheen Sarkar
Date Deposited: 12 Jan 2015 02:03
Last Modified: 14 Feb 2018 04:12
URI: http://umpir.ump.edu.my/id/eprint/8176
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