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Solid phase transformation of carbamazepine-succinic co-crystal

Engku Nadia, Engku Mat Nasir (2014) Solid phase transformation of carbamazepine-succinic co-crystal. Faculty of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang.

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Abstract

This paper presents the solid phase transformation of carbamazepine-succinic co-crystal. Solvent evaporation, slurry crystallization and cooling crystallization are the three techniques which represent the solution based method were used. In this study ethanol was used as solvent. CBZ-SUC co-crystals formations are studied by varying the mol ratio of CBZ and SUC. The CBZ-SUC co-crystals formation was characterized by using X-ray powder diffraction (XRPD), and optical microscopy. From the XRPD pattern profile, it shows that the co-crystals were formed for all the ratio of CBZ and SUC by the slurry crystallization and cooling crystallization. The results shows that the pattern profiles representing the co-crystal as no peak are develop with the raw material peak. The morphology of the co-crystals formation is needle-like co-crystals for cooling crystallization and solvent evaporation. The morphology of slurry crystallization is difficult to characterize due to agglomeration effects. Results from this research may be useful in pharmaceutical industry as the co-crystals are successfully formed.

Item Type: Undergraduates Project Papers
Additional Information: Faculty of Chemical & Natural Resources Engineering Project paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang – 2014
Uncontrolled Keywords: Crystallization; Carbamazepine
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Chemical & Natural Resources Engineering
Depositing User: Nik Ahmad Nasyrun Nik Abd Malik
Date Deposited: 22 Oct 2015 01:10
Last Modified: 22 Oct 2015 01:11
URI: http://umpir.ump.edu.my/id/eprint/9076
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