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Effect on Operating Parameters Towards Metastable Zone Width of Carbamazepine-Saccharin Co-Crystal

E. N., Engku Mat Nasir and Fatinah, Ab Rahman and S., Abd Rahim and Raihana Z., Edros and N., Anuar (2016) Effect on Operating Parameters Towards Metastable Zone Width of Carbamazepine-Saccharin Co-Crystal. In: The 18th International Conference on Crystal Growth and Epitaxy, 07-12 August 2016 , Nagoya, Japan. . (Unpublished)

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Abstract

Co-crystal is believed can improved physicochemical properties of an Active Pharmaceutical Ingredients (APis). Understanding in co-crystallization process is needed in order to have desirable crystal habits for materials. One of the studies that are important in designing co-crystallization process is kinetics study. In this research, carbamazepine (CBZ) and co-former saccharin (SAC) has been used to study the metastable zone width (MSZW) of the CBZ-SAC co-crystal in ethanol solution. The MSZW is studied by varying concentration of CBZ, mo) ratio values of SAC to CBZ and cooling rates used by polythermal method. Crystallization temperature and dissolution temperature is used to determine the maximum temperature difference ~Tmax using N)'vlt's equation.

Item Type: Conference or Workshop Item (Speech)
Uncontrolled Keywords: Co-crystal
Subjects: T Technology > T Technology (General)
T Technology > TP Chemical technology
Faculty/Division: Faculty of Chemical & Natural Resources Engineering
Faculty of Engineering Technology
Institute of Postgraduate Studies
Depositing User: Ms. Siti Nur Sahidah Ahmad
Date Deposited: 02 Jun 2017 03:32
Last Modified: 30 Oct 2019 07:39
URI: http://umpir.ump.edu.my/id/eprint/17064
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