Engku Nadia, Engku Mat Nasir and Fatinah, Ab Rahman and Syarifah, Abd Rahim and Raihana Z., Edros and Nornizar, Anuar (2017) Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal. Indian Journal of Science and Technology, 10 (7). pp. 1-5. ISSN 0974-6846 (Print); 0974-5645 (Online). (Published)
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Abstract
Objectives: Metastable zone width (MSZW) is a crucial parameter in designing co-crystallization process in order to achieve required crystal habits. The effects of operating parameters toward metastable zone width of carbamazepine-saccharin (CBZ-SAC) co-crystal were studied in this research. Methods/Statistical Analysis: Crystallization study was conducted using cooling crystallization method which involves polythermal method. A 250 ml scale size-reactor was used to study the effects of operating parameters on metastable zone width of CBZ-SAC co-crystal which tested with various mol ratio of SAC/CBZ, concentration of CBZ, cooling and heating rates and stirring speeds. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and optical microscopy were applied to characterize the CBZ-SAC co-crystals. Findings: The results show that MSZW decreases as the mol ratios of SAC/CBZ increases, whilst also decreases with CBZ concentrations, cooling rates and stirring speeds. Application/Improvements: Cooling crystallization process is extensively used in the manufacture of pharmaceutical drugs.
| Item Type: | Article |
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| Uncontrolled Keywords: | Co-Crystal, Metastable Zone Width, Nucleation Kinetics, Polythermal Method |
| Subjects: | T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Chemical & Natural Resources Engineering Faculty of Engineering Technology Institute of Postgraduate Studies |
| Depositing User: | Noorul Farina Arifin |
| Date Deposited: | 11 Apr 2017 07:17 |
| Last Modified: | 30 Oct 2019 07:38 |
| URI: | http://umpir.ump.edu.my/id/eprint/17467 |
| Download Statistic: | View Download Statistics |
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