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Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal

Engku Nadia, Engku Mat Nasir and Fatinah, Ab Rahman and Syarifah, Abd Rahim and Raihana Z., Edros and Nornizar, Anuar (2017) Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal. Indian Journal of Science and Technology, 10 (7). pp. 1-5. ISSN 0974-6846 (Print); 0974-5645 (Online)

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Objectives: Metastable zone width (MSZW) is a crucial parameter in designing co-crystallization process in order to achieve required crystal habits. The effects of operating parameters toward metastable zone width of carbamazepine-saccharin (CBZ-SAC) co-crystal were studied in this research. Methods/Statistical Analysis: Crystallization study was conducted using cooling crystallization method which involves polythermal method. A 250 ml scale size-reactor was used to study the effects of operating parameters on metastable zone width of CBZ-SAC co-crystal which tested with various mol ratio of SAC/CBZ, concentration of CBZ, cooling and heating rates and stirring speeds. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and optical microscopy were applied to characterize the CBZ-SAC co-crystals. Findings: The results show that MSZW decreases as the mol ratios of SAC/CBZ increases, whilst also decreases with CBZ concentrations, cooling rates and stirring speeds. Application/Improvements: Cooling crystallization process is extensively used in the manufacture of pharmaceutical drugs.

Item Type: Article
Uncontrolled Keywords: Co-Crystal, Metastable Zone Width, Nucleation Kinetics, Polythermal Method
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Chemical & Natural Resources Engineering
Faculty of Engineering Technology
Depositing User: Noorul Farina Arifin
Date Deposited: 11 Apr 2017 07:17
Last Modified: 13 Dec 2017 03:03
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