Mohd Jamil Mohamed, Mokhtarudin and Payne, Stephen J. (2017) The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory. International Journal for Numerical Methods In Biomedical Engineering, 33 (1). pp. 1-14. ISSN 2040-7939 (print); 2040-7947 (online). (Published)
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Abstract
Brain oedema is thought to form and to clear through the use of water-protein channels, aquaporin-4 (AQP4), which are found in the astrocyte endfeet. The model developed here is used to study the function of AQP4 in the formation and elimination of oedema fluid in ischaemia-reperfusion injury. The cerebral space is assumed to be made of four fluid compartments: astrocyte, neuron, ECS and blood microvessels, and a solid matrix for the tissue, and this is modelled using multiple-network poroelastic theory. AQP4 allows the movement of water between astrocyte and the ECS and the microvessels. It is found that the presence of AQP4 may help in reducing vasogenic oedema shown by a decrease in brain tissue extracellular pressure. However, the astrocyte pressure will increase to compensate for this decrease, which may lead to cytotoxic oedema. In addition, the swelling will also depend on the ionic concentrations in the astrocyte and extracellular space, which may change after ischaemic stroke. Understanding the role of AQP4 in oedema may thus help the development of a treatment plan in reducing brain swelling after ischaemia-reperfusion.
| Item Type: | Article |
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| Uncontrolled Keywords: | poroelastic theory; AQP4; vasogenic oedema; blood–brain barrier; ischaemia–reperfusion injury |
| Subjects: | T Technology > TJ Mechanical engineering and machinery |
| Faculty/Division: | Faculty of Mechanical Engineering |
| Depositing User: | Noorul Farina Arifin |
| Date Deposited: | 01 Jun 2017 07:28 |
| Last Modified: | 29 Aug 2018 03:15 |
| URI: | http://umpir.ump.edu.my/id/eprint/17822 |
| Download Statistic: | View Download Statistics |
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