S. N., Mohamad Aziz and Mimi Sakinah, A. M. (2017) The Solubilization and Extraction Parameters of Erythromycin from Aqueous Phase Into Mixed AOT/SB3-18 Reverse Micelle Phase. Chemical Engineering Research Bulletin, 19 (Special). pp. 123-128. ISSN 0379-7678 (Print); 2072-9510 (Online). (Published)
|
PDF
The Solubilization and Extraction Parameters of Erythromycin from Aqueous Phase Into Mixed AOT-SB3- 18 Reverse Micelle Phase.pdf Download (326kB) | Preview |
Abstract
A liquid anionic-zwitterionic surfactant-based aqueous two-phase extraction was developed and applied for the extraction of erythromycin. Erythromycin solubilization from aqueous to reverse micelle phase was studied. Zwitterion SB3-18 surfactant was added to ionic solution of bis(2-ethylhexyl) sulfosuccinate sodium salt (AOT) to form an organic mixed micellar phase. Erythromycin was then added to the mixtures and two clear phases were formed. The parameters affecting erythromycin solubilization including AOT concentration (20.0 ? 120.0 g/L), zwitterion concentration (6.0 ? 16.0 g/L), NaCl concentration (0.0 ? 25.0 g/L) and aqueous pH (6.0 ? 9.0) were investigated via statistical software. Solubilization of erythromycin into mixed reverse micelle could be easily evaluated by the measurement of erythromycin concentration in the organic phase. The results showed that AOT and zwitterion concentration governed the erythromycin solubilization by a factor of 4.562 based on the Pareto chart.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Solubilization; Erythromycin; Mixed micellar phase |
| Subjects: | T Technology > T Technology (General) |
| Faculty/Division: | Faculty of Engineering Technology |
| Depositing User: | Mrs. Neng Sury Sulaiman |
| Date Deposited: | 23 Feb 2018 02:58 |
| Last Modified: | 23 Feb 2018 02:58 |
| URI: | http://umpir.ump.edu.my/id/eprint/20605 |
| Download Statistic: | View Download Statistics |
Actions (login required)
 |
View Item |