Trinh Duy, Nguyen and Hieu, Vu-Quang and Thanh, Sang Vo and Duy, Chinh Nguyen and Dai-Viet, N. Vo and Dai Hai, Nguyen and Kwon, Taek Lim and Dai, Lam Tran and Long, Giang Bach (2019) Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine. Polymers, 11 (1). pp. 1-12. ISSN 2073-4360. (Published)
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Abstract
This paper describes the functionalization of poly(poly(ethylene glycol) methacrylate) (PPEGMA)-grafted CdTe (PPEGMA-g-CdTe) quantum dots (QDs) via surface-initiated reversible addition–fragmentation chain transfer (SI-RAFT) polymerization for immobilization of adenosine. Initially, the hydroxyl-coated CdTe QDs, synthesized using 2-mercaptoethanol (ME) as a capping agent, were coupled with a RAFT agent, S-benzyl S′ trimethoxysilylpropyltrithiocarbonate (BTPT), through a condensation reaction. Then, 2,2′-azobisisobutyronitrile (AIBN) was used to successfully initiate in situ RAFT polymerization to generate PPEGMA-g-CdTe nanocomposites. Adenosine-above-PPEGMA-grafted CdTe (Ado-i-PPEGMA-g-CdTe) hybrids were formed by the polymer shell, which had successfully undergone bioconjugation and postfunctionalization by adenosine (as a nucleoside). Fourier transform infrared (FT-IR) spectrophotometry, energy-dispersive X-ray (EDX) spectroscopy, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy results indicated that a robust covalent bond was created between the organic PPEGMA part, cadmium telluride (CdTe) QDs, and the adenosine conjugate. The optical properties of the PPEGMA-g-CdTe and Ado-i-PPEGMA-g-CdTe hybrids were investigated by photoluminescence (PL) spectroscopy, and the results suggest that they have a great potential for application as optimal materials in biomedicine.
| Item Type: | Article |
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| Additional Information: | Trinh Duy Nguyen, Hieu Vu-Quang, Thanh Sang Vo, Duy Chinh Nguyen, Dai-Viet N. Vo, Dai Hai Nguyen, Kwon Taek Lim, Dai Lam Tran and Long Giang Bach Indexed by Scopus and Web of Science |
| Uncontrolled Keywords: | CdTe quantum dots; Poly(poly(ethylene glycol methacrylate); SI-RAFT; Adenosine; Covalent immobilization |
| Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Chemical & Natural Resources Engineering |
| Depositing User: | Mrs Norsaini Abdul Samat |
| Date Deposited: | 19 Apr 2019 07:59 |
| Last Modified: | 19 Apr 2019 07:59 |
| URI: | http://umpir.ump.edu.my/id/eprint/24748 |
| Download Statistic: | View Download Statistics |
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