Mohamed, Shazmin Kithur and Asif, Muhammad and Nazari, Mansoureh Vishkaei and Baharetha, Hussein M. and Mahmood, Syed and Abdul Rashid, M. Yatim and Aman Shah, Abdul Majid and Abdul Majid, Amin Malik Shah (2019) Antiangiogenic activity of sophorolipids extracted from refined bleached deodorized palm olein. Indian Journal of Pharmacology, 51 (1). pp. 45-54. ISSN 0253-7613. (Published)
|
Pdf
Antiangiogenic activity of sophorolipids extracted from refined bleached.pdf Download (275kB) | Preview |
Abstract
OBJECTIVES: Sophorolipids (SLs) are a group of surface-active glycolipids produced by a type of nonpathogenic yeast Candida bombicola in the presence of vegetable oil through fermentation technology. SLs have shown antitumor activity; however, the mechanism of action underlying the anticancer activity of SLs is poorly understood. This work evaluated the anticancer activity of SLs fermented from palm oil by exploring its antiangiogenic activity. MATERIALS AND METHODS: The SLs that were fermented and further characterized for their biochemical activities. Cytotoxicity study was performed to assess cytostatic properties. A series of in vitro and ex vivo angiogenesis assay was also carried out. The relative fold change in the expression of p53 mRNA by SLs was also studied. RESULTS: Altogether, the data show that SLs derived from palm oil fermentation process inhibited neovascularization in the ex vivo tissue segments and also the endothelial cell proliferation between 50% and 65% inhibition as a whole. The palm oil derived SLs also caused downregulation of the suppression level of vascular endothelial growth factor and also upregulate the p53 mRNA level. The analytical studies revealed the presence of high amount of phenolic compounds but with relatively weak antioxidant activity. The gas chromatography-mass spectrometry studies revealed abundant amount of palmitic and oleic acid, the latter an established antiangiogenic agent, and the former being proangiogenic. CONCLUSION: Therefore, it can be concluded from this study that SLs derived from fermented palm oil have potent antiangiogenic activity which may be attributed by its oleic acid component.
| Item Type: | Article |
|---|---|
| Additional Information: | Shazmin Kithur Mohamed, Muhammad Asif, Mansoureh Vishkaei Nazari, Hussein M Baharetha, Syed Mahmood, Abdul Rashid M. Yatim, Aman Shah Abdul Majid, Amin Malik Shah Abdul Majid; Indexed by Scopus |
| Uncontrolled Keywords: | Antiangiogenic; Anticancer; Fermentation; Palm oil; Sophorolipids |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Engineering Technology |
| Depositing User: | Mrs Norsaini Abdul Samat |
| Date Deposited: | 30 May 2019 08:29 |
| Last Modified: | 30 May 2019 08:29 |
| URI: | http://umpir.ump.edu.my/id/eprint/24986 |
| Download Statistic: | View Download Statistics |
Actions (login required)
 |
View Item |