Chia, Vi Vien and Pang, Sook Fun and Sureena, Abdullah and M. M., Yusoff and Jolius, Gimbun (2019) POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata. In: Proceedings of the 5th Postgraduate Colloquium for Environmental Research (POCER 2019) , 8-9 August 2019 , Putrajaya, Malaysia. pp. 39-41., 8. ISBN 978-967-11279-6-4
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Abstract
In this study, a central composite design was employed to optimize the process variables, i.e., microwave power (75-175 W) and ethanol concentration (20-85%) on the yield of bioactive compound extraction from Andrographis paniculata. The regression analysis shows a good fit between the experimental data to the second-order polynomial model with a coefficient of determination (R2) value of ≈ 0.95. The optimum conditions to maximize the yield of andrographolide, 14-deoxy-11,12-didehydroandrographolide, and neoandrographolide were found at microwave power of 140 W and 85% ethanol. Experimental validation performed at the aforementioned conditions yielded AND (10.93 ± 0.053 mg/gDW), DDA (4.34 ± 0.215 mg/gDW), and NEA (5.70 ± 0.252 mg/gDW), which are comparable to those of model prediction, i.e., 10.426 mg/gDW of AND, 4.123 mg/gDW of DDA and 5.558 mg/gDW of NEA, indicating the suitability of the developed models.
| Item Type: | Conference or Workshop Item (Lecture) |
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| Uncontrolled Keywords: | Andrographis paniculata; optimization; terpenes; central composite design |
| Subjects: | T Technology > TP Chemical technology |
| Faculty/Division: | Centre of Excellence: Centre of Excellence for Advanced Research in Fluid Flow Faculty of Chemical & Natural Resources Engineering Faculty of Industrial Sciences And Technology |
| Depositing User: | Prof. Dr. Jolius Gimbun |
| Date Deposited: | 16 Dec 2019 07:46 |
| Last Modified: | 16 Dec 2019 08:01 |
| URI: | http://umpir.ump.edu.my/id/eprint/26833 |
| Download Statistic: | View Download Statistics |
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