Ukaegbu, Chinonso Ishmael and Rashid, Shah Samiur and Hazrulrizawati, Hamid and Alara, Oluwaseun Ruth and Sarker, Zaidul Islam (2020) Phenolic compounds of aqueous and methanol extracts of hypsizygus tessellatus (brown and white var.) and flammulina velutipes caps : antioxidant and antiproliferative activities. Pharmaceutical Chemistry Journal, 54 (2). pp. 170-183. ISSN 0091-150X. (Published)
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Abstract
Since the World Health Organization has suggested the exploration of natural products for cancer management owing to the side effects of chemotherapy and irradiation on humans and breast cancer accounts for the highest number of cancer related deaths globally, this study has examined antiproliferative effects of the aqueous and methanol extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes caps against two breast cancer cell lines. The antioxidant and antiproliferative activities of these mushroom extracts were evaluated in vitro using chemical-based (for antioxidant activity) and cell (for antiproliferative activity) approaches. Furthermore, the phytochemical composition of the mushroom extracts were identified using mass spectroscopy (UPLC-QTOF/MS). The obtained results showed aqueous extracts of F. velutipes (Enoki) and white H. tessellatus (Bunapi shimeji) caps to possess higher antiodixant activities against DPPH (IC50 = 0.202 and 0.573 mg/mL, respectively), and H2O2 (IC50 = 0.622 and 0.745 mg/mL, respectively) compared tothe methanol extracts. Aqueous extracts of the mushrooms also showed better ferric reducing antioxidant power (FRAP) values against ferric ions compared to the methanol extracts. Finally, the mushroom extracts showed good antiproliferative activities against human breast cancer cell lines. These findings suggest the presence of phytochemicals with antiproliferative and antioxidant acrtivities in the mushroom extracts studied.
| Item Type: | Article |
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| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Antioxidant; antiproliferative; F. Velutipes; H. tessellatus; phytochemicals |
| Subjects: | T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Industrial Sciences And Technology Institute of Postgraduate Studies |
| Depositing User: | Mrs Norsaini Abdul Samat |
| Date Deposited: | 03 Nov 2022 09:49 |
| Last Modified: | 03 Nov 2022 09:49 |
| URI: | http://umpir.ump.edu.my/id/eprint/28680 |
| Download Statistic: | View Download Statistics |
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