Subashini, Raman and Mahmood, Syed and Ayah, R. Hilles and Javed, M. Noushad and Azmana, Motia and AL-japairai, Khater Ahmed Saeed (2020) Polymeric Nanoparticles for Brain Drug Delivery - A Review. Current Drug Metabolism, 21 (9). pp. 649-660. ISSN 1875-5453. (Published)
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Abstract
Background: Blood-brain barrier (BBB) is playing a most hindering role in drug delivery to the brain. Recent research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the brain. Currently, polymeric nanoparticle is extensively involved in many therapies for spatial and temporal targeted areas delivery. Methods: We did a non-systematic review, and the literature was searched in Google, Science Direct and PubMed. An overview is provided for the formulation of polymeric nanoparticles using different methods, effect of surface modification on the nanoparticle properties with types of polymeric nanoparticles and preparation methods. An account of different nanomedicine employed with therapeutic agent to cross the BBB alone with biodistribution of the drugs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Brain delivery, polymer, nanoparticles, nanomedicine, biodistribution, nanomedicine |
| Subjects: | T Technology > TP Chemical technology |
| Faculty/Division: | Institute of Postgraduate Studies Faculty of Chemical and Process Engineering Technology |
| Depositing User: | Noorul Farina Arifin |
| Date Deposited: | 19 Aug 2020 08:02 |
| Last Modified: | 05 Feb 2021 03:50 |
| URI: | http://umpir.ump.edu.my/id/eprint/29112 |
| Download Statistic: | View Download Statistics |
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