Rahman, Md. Shahedur and Biswas, Chayon and Biswas, Polash Kumar and Kader, Md. Ashraful and Nur Alam, S. M. and Sonne, Christian and Kim, Ki-Hyun (2020) In silico analysis of the antigenic properties of iron-regulated proteins against neisseria meningitides. Applied Sciences, 10 (17). pp. 1-12. ISSN 2076-3417. (Published)
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Abstract
Neisseria meningitidis is a commensal pathogen that causes infectious cerebrospinal disease in people of all ages. The multivariate role of six disease-causing polysaccharide serotypes is found to play a crucial role in developing vaccines (or general treatment strategies) to treat this emerging pathogen. Iron is a crucial transition metal for N. meningitidis. Proteomic analysis data could be valuable for vaccine design. Here, we conduct a comparative study using computational bioinformatic tools to identify the most effective iron-regulated outer membrane proteins (OMPs) as immunogenic targets for a potential vaccine against N. meningitidis. The basic properties of N. meningitidis OMPs are explored for flexibility, solubility, hydrophilicity, beta-turns, and overall antigenic probability. Results of our study suggest that iron-regulated OMPs are flexible and soluble in water with high densities of conformational B-cell epitopes. As such, they can be recommended as a novel candidate for a vaccine against N. meningitidis both in vitro and in vivo.
| Item Type: | Article |
|---|---|
| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Neisseria meningitidis; Vaccine development; Epidemic disease; Immunogenicity |
| Subjects: | T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Industrial Sciences And Technology Institute of Postgraduate Studies |
| Depositing User: | Mrs Norsaini Abdul Samat |
| Date Deposited: | 21 Jun 2022 02:00 |
| Last Modified: | 21 Jun 2022 02:00 |
| URI: | http://umpir.ump.edu.my/id/eprint/29984 |
| Download Statistic: | View Download Statistics |
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