Pal, Arpita and Roy, Sudeep and Kumar, Akhil and Mahmood, Syed and Nasrin, Khodapanah and Thomas, Sabu and Agatemor, Christian and Ghosal, Kajal (2020) Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes. ACS Omega, 5 (32). pp. 19968-19977. ISSN 2470-1343. (Published)
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Abstract
This present study investigated the effect of Captisol, a chemically modified cyclodextrin, on the in vitro dissolution of glimepiride. We prepared glimepiride–Captisol complexes of different mass ratios (1:1, 1:2, and 1:3 w/w) by a physical mixing or freeze-drying technique, and found that complexation with Captisol enhanced the water solubility of glimepiride. Molecular docking and dynamic simulation predicted complex formation; at the same time, Fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffractometry, and scanning electron microscope indicated molecular interactions that support complexation. We also found that an inclusion complex was better than a physical mixture in enhancing the complexation of glimepiride with Captisol and enhancing water solubility. Phase solubility study of the glimepiride–Captisol complex showed an AL-type profile, implying the formation of a 1:1 inclusion complex. The study also revealed that pH influenced the stability of the complex because the stability constant of the glimepiride–Captisol complex was higher in distilled water of pH ∼6.0 than in phosphate buffer of pH 7.2.
| Item Type: | Article |
|---|---|
| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Macrocyclic compounds; Oligosaccharides; Mixtures; Dissolution; Solubility |
| Subjects: | T Technology > TP Chemical technology |
| Faculty/Division: | Centre of Excellence: Centre of Excellence for Advanced Research in Fluid Flow Faculty of Engineering Technology Faculty of Chemical and Process Engineering Technology |
| Depositing User: | Mrs Norsaini Abdul Samat |
| Date Deposited: | 09 Jul 2021 02:27 |
| Last Modified: | 09 Jul 2021 02:27 |
| URI: | http://umpir.ump.edu.my/id/eprint/31392 |
| Download Statistic: | View Download Statistics |
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