Hossain, Sanower and Urbi, Zannat and Hidayah, Karuniawati and Ramisa, Mohiuddin and Qrimida, Ahmed Moh and Mohamed Masaud Allzrag, Akrm and Ming, Long Chiau and Pagano, Ester and Capasso, Raffaele (2021) Andrographis paniculata (Burm. f.) wall. ex nees: An updated review of phytochemistry, antimicrobial pharmacology, and clinical safety and efficacy. Life, 11 (4). pp. 1-39. ISSN 2075-1729. (Published)
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Andrographis paniculata (Burm. f.) wall. ex nees_An updated review of phytochemistry, antimicrobial pharmacology.pdf Available under License Creative Commons Attribution. Download (7MB) | Preview |
Abstract
Infectious disease (ID) is one of the top-most serious threats to human health globally, further aggravated by antimicrobial resistance and lack of novel immunization options. Andrographis paniculata (Burm. f.) Wall. ex Nees and its metabolites have been long used to treat IDs. Andrographolide, derived from A. paniculata, can inhibit invasive microbes virulence factors and regulate the host immunity. Controlled clinical trials revealed that A. paniculata treatment is safe and efficacious for acute respiratory tract infections like common cold and sinusitis. Hence, A. paniculata, mainly andrographolide, could be considered as an excellent candidate for antimicrobial drug development. Considering the importance, medicinal values, and significant role as antimicrobial agents, this study critically evaluated the antimicrobial therapeutic potency of A. paniculata and its metabolites, focusing on the mechanism of action in inhibiting invasive microbes and biofilm formation. A critical evaluation of the secondary metabolites with the aim of identifying pure compounds that possess antimicrobial functions has further added significant values to this study. Notwithstanding that A. paniculata is a promising source of antimicrobial agents and safe treatment for IDs, further empirical research is warranted.
| Item Type: | Article |
|---|---|
| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Antimicrobial agent; Clinical trial; Ethnopharmacology; Infectious disease; Medicinal plant; Metabolites; Natural products |
| Subjects: | T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Industrial Sciences And Technology Institute of Postgraduate Studies |
| Depositing User: | Mr Muhamad Firdaus Janih@Jaini |
| Date Deposited: | 08 Mar 2022 05:06 |
| Last Modified: | 08 Mar 2022 05:06 |
| URI: | http://umpir.ump.edu.my/id/eprint/32771 |
| Download Statistic: | View Download Statistics |
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