Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation

Nuramira Fateha, Sukor and Rohayu, Jusoh and Nur Syahirah, Kamarudin (2023) Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation. In: Materials Today: Proceedings. The 6th National Conference for Postgraduate Research (NCON-PGR 2022) , 15 November 2022 , Virtual Conference, Universiti Malaysia Pahang, Malaysia. pp. 1-7.. ISSN 2214-7853 (In Press / Online First)

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Abstract

The current study offers controlled release of niacinamide from fibrous silica (KCC-1) loaded in a face serum formulation. Furthermore, three drug loading methods, namely physical mixing, melting, and solvent evaporation, denoted as (Phy)/Nia-KCC-1, (Mel)/Nia-KCC-1, and (Sol)/Nia-KCC-1, respectively, were implemented, and the percentage loading efficiencies were compared. (Mel)/Nia-KCC-1 demonstrated the highest percentage of drug loading at 33%, followed by (Phy)/Nia-KCC-1 and (Sol)/Nia-KCC-1 at 25% and 17%, respectively. Likewise, the in vitro release study also revealed a similar pattern, with (Mel)/Nia-KCC-1 recording the highest percentage release at 29%, followed by (Phy)/Nia-KCC-1 and (Sol)/Nia-KCC-1 at 24% and 21%, respectively. As the (Mel)/Nia-KCC-1 sample unveiled decent results in transporting the sample drug, the respective sample was then further loaded into the face serum formulation, and the pH stability was observed for 7 days. The pH readings remained constant at pH 4.3 throughout the 7 days, within the acceptance range according to the derma-cosmetic product that states the effective pH should lie between pH 4 and pH 6. Therefore, it can be stated that the (Mel)/Nia-KCC-1 loaded serum fulfills the acceptance criteria for the pH requirement of derma-cosmetic products.

Item Type:	Conference or Workshop Item (Lecture)
Uncontrolled Keywords:	Controlled release; Niacinamide; Fibrous silica; Drug loading; Serum formulation.
Subjects:	Q Science > QD Chemistry T Technology > TP Chemical technology
Faculty/Division:	Institute of Postgraduate Studies Faculty of Chemical and Process Engineering Technology
Depositing User:	Mr Muhamad Firdaus Janih@Jaini
Date Deposited:	30 Jan 2023 08:25
Last Modified:	23 Apr 2024 07:48
URI:	http://umpir.ump.edu.my/id/eprint/36797
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