Nuramira Fateha, Sukor and Rohayu, Jusoh and Nur Syahirah, Kamarudin (2023) Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation. In: Materials Today: Proceedings. The 6th National Conference for Postgraduate Research (NCON-PGR 2022) , 15 November 2022 , Virtual Conference, Universiti Malaysia Pahang, Malaysia. pp. 1-7.. ISSN 2214-7853 (In Press / Online First)
|
Pdf
Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation.pdf Download (334kB) | Preview |
|
![]() |
Pdf
Controlled release of niacinamide from fibrous silica nanocarrier.pdf Restricted to Repository staff only Download (1MB) | Request a copy |
|
|
Pdf
Controlled release of niacinamide_ABST.pdf Download (222kB) | Preview |
Abstract
The current study offers controlled release of niacinamide from fibrous silica (KCC-1) loaded in a face serum formulation. Furthermore, three drug loading methods, namely physical mixing, melting, and solvent evaporation, denoted as (Phy)/Nia-KCC-1, (Mel)/Nia-KCC-1, and (Sol)/Nia-KCC-1, respectively, were implemented, and the percentage loading efficiencies were compared. (Mel)/Nia-KCC-1 demonstrated the highest percentage of drug loading at 33%, followed by (Phy)/Nia-KCC-1 and (Sol)/Nia-KCC-1 at 25% and 17%, respectively. Likewise, the in vitro release study also revealed a similar pattern, with (Mel)/Nia-KCC-1 recording the highest percentage release at 29%, followed by (Phy)/Nia-KCC-1 and (Sol)/Nia-KCC-1 at 24% and 21%, respectively. As the (Mel)/Nia-KCC-1 sample unveiled decent results in transporting the sample drug, the respective sample was then further loaded into the face serum formulation, and the pH stability was observed for 7 days. The pH readings remained constant at pH 4.3 throughout the 7 days, within the acceptance range according to the derma-cosmetic product that states the effective pH should lie between pH 4 and pH 6. Therefore, it can be stated that the (Mel)/Nia-KCC-1 loaded serum fulfills the acceptance criteria for the pH requirement of derma-cosmetic products.
Item Type: | Conference or Workshop Item (Lecture) |
---|---|
Uncontrolled Keywords: | Controlled release; Niacinamide; Fibrous silica; Drug loading; Serum formulation. |
Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
Faculty/Division: | Institute of Postgraduate Studies Faculty of Chemical and Process Engineering Technology |
Depositing User: | Mr Muhamad Firdaus Janih@Jaini |
Date Deposited: | 30 Jan 2023 08:25 |
Last Modified: | 23 Apr 2024 07:48 |
URI: | http://umpir.ump.edu.my/id/eprint/36797 |
Download Statistic: | View Download Statistics |
Actions (login required)
![]() |
View Item |