Nurul Izzati, Azahar and Swan, Sia Yiik and Nur Syahirah, Mohd Razi and Zhen, Wan Yan and Mohd Azmir, Arifin (2023) Evaluation of antioxidant, antibacterial and anticancer activities of ganoderma lucidum extracts. In: Materials Today: Proceedings. The 6th National Conference for Postgraduate Research (NCON-PGR 2022) , 15 November 2022 , Virtual Conference, Universiti Malaysia Pahang, Malaysia. pp. 1-10.. ISSN 2214-7853 (In Press / Online First)
|
Pdf
Evaluation of antioxidant, antibacterial and anticancer activities of ganoderma lucidum extracts.pdf Download (454kB) | Preview |
|
![[img]](http://umpir.ump.edu.my/style/images/fileicons/other.png) |
Pdf
Evaluation of antioxidant antibacterial and anticancer activities_FULL.pdf Restricted to Repository staff only Download (2MB) | Request a copy |
|
|
Pdf
Evaluation of antioxidant antibacterial and anticancer activities.pdf Download (272kB) | Preview |
Abstract
G. lucidum is an oriental fungus loaded with antioxidant, antimicrobial and anticancer properties. G. lucidum extracts obtained by using soxhlet and Ultrasonic-Assisted Extraction (UAE). The antioxidant activity determined by DPPH assay resulting in IC50 value of extract for soxhlet water 372.21μg/mL followed by soxhlet ethanol 431.00μg/mL, UAE ethanol 541μg/mL and UAE water 560.90μg/mL shown weak antioxidant properties. Well plate diffusion used for antimicrobial activity test against E. coli and S. aureus. The UAE water extract shown highest antibacterial activity against S. aureus (20-23) mm followed by soxhlet water extract (6-13) mm. The ethanol extract for both soxhlet and UAE are (5-13) mm and (4-14) mm respectively. G. lucidum extract exhibited zero inhibition zone against E. coli due to presence of barrier membrane. CCK-8 used to test anticancer activity against MCF-7 cells. The IC50 values of soxhlet ethanolic extract is 4.797 μg/mL followed by UAE ethanolic extract 5.291 μg/mL, soxhlet water extract 7.196 μg/mL and UAE water extracts 9.455 μg/mL. The lower IC50 value indicated that the extracts inhibited cell viability of MCF-7.
| Item Type: | Conference or Workshop Item (Lecture) |
|---|---|
| Uncontrolled Keywords: | Ganoderma lucidum; GC-MS; Antioxidant; Antimicrobial; Anticancer |
| Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
| Faculty/Division: | Institute of Postgraduate Studies Faculty of Chemical and Process Engineering Technology |
| Depositing User: | Mr Muhamad Firdaus Janih@Jaini |
| Date Deposited: | 20 Feb 2023 04:09 |
| Last Modified: | 23 Apr 2024 07:54 |
| URI: | http://umpir.ump.edu.my/id/eprint/36880 |
| Download Statistic: | View Download Statistics |
Actions (login required)
 |
View Item |