Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling

Siti Munirah, Muhammad Ali and El-Bouri, Wahbi K. and Mohd Jamil, Mohamed Mokhtarudin (2022) Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling. In: 7th IEEE-EMBS Conference on Biomedical Engineering and Sciences, IECBES 2022 - Proceedings , 7-9 December 2022 , Virtual, Online. pp. 160-164. (187642). ISBN 978-166549469-4

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Abstract

Age is a major risk for heart failure, which is associated with the reduction in ventricular compliance, increase in arterial stiffening, and increase in systemic vascular resistance. In this study, a lumped-parameter model is used to investigate the effect of aging on the possibility of heart failure occurrence. Model parameters including the systemic and pulmonary arterial compliance and resistance, and the left ventricular elastance are calculated for different ages using a ratio-based method. These parameters are then used in the lumped-parameter model. Our findings show that as age increases, there is a leftward and a rightward shift in the left ventricle and right ventricle pressure-volume loops, respectively. For the left ventricle, there is a decrease in stroke volume and an increase in ventricular pressure as the age increases. This correlates with the occurrence of arterial hypertension in the older population. Meanwhile, the right ventricular pressure is maintained as the population gets older, despite the increase in the stroke volume. This is possibly due to the shift in intraventricular septum that causes an enlargement of the right ventricle as the age increases. This study provides understanding on the effect of age on the occurrence of heart failure.This study demonstrates the relationship of aging with cardiac hemodynamics, which provides the potential risk of heart failure occurrence. Although there are many risk factors that can cause heart failure, aging has been strongly associated with its occurrence. Understanding how age affects heart failure can help to differentiate them from other effects such as dietary, gender, and early cardiovascular diseases including arrhythmia and myocardial infarction.

Item Type:	Conference or Workshop Item (Paper)
Additional Information:	Indexed by Scopus
Uncontrolled Keywords:	Blood pressure; Cardiology; Diseases; Heart; Lumped parameter networks; Sensitivity analysis
Subjects:	T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General) T Technology > TJ Mechanical engineering and machinery T Technology > TK Electrical engineering. Electronics Nuclear engineering T Technology > TS Manufactures
Faculty/Division:	Institute of Postgraduate Studies College of Engineering Faculty of Manufacturing and Mechatronic Engineering Technology
Depositing User:	Mr Muhamad Firdaus Janih@Jaini
Date Deposited:	14 Nov 2023 03:39
Last Modified:	14 Nov 2023 03:39
URI:	http://umpir.ump.edu.my/id/eprint/39079
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