Nurul Haiza, Sapiee and Muhammad Hasif, Mat Saufi and Noor Fitrah, Abu Bakar and Fatmawati, Adam (2023) Fabrication and characterization of electrospun κ-carrageenan based oral dispersible film with vitamin C. Materials Today: Proceedings. pp. 1-6. ISSN 2214-7853. (In Press / Online First) (In Press / Online First)
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Abstract
Oral dispersible films (ODF) are great alternatives to tablet medications as they will simply dissolve in the mouth. There are several ways to produce ODFs, but electrospinning is emerging as one of the best methods as it increases the surface to volume ratio which allows it to dissolve easily. ODFs are typically formulated using a combination of polymers to produce the necessary film qualities. The use of κ-carrageenan (κ-CAR), a natural polymer in ODFs are yet to be studied in detail. Therefore, this study aims to develop an ODF from a combination of κ-CAR, polyvinyl alcohol (PVA) and vitamin C, where the latter will act as a model drug carrier. 1.5w/v% κ-CAR and 14w/v% PVA at a ratio of 30:70 was added with different concentrations of vitamin C from 2 to 10w/v%, respectively. The resulting nanofibers were then examined for morphology, water contact angle (WCA) and disintegration time. All the solutions formed uniform nanofibers with an average diameter ranging from 190 to 490 nm and showed hydrophilic properties. Sample 4 showed the fastest disintegration time of 3.68 s and the lowest WCA of 38.5°. The results indicated that the best formulation for an ODF was with 8% vitamin C. The findings from this study provide promising groundwork for the use of κ-CAR as the biopolymer in combination with the PVA to develop a biopolymer-based ODF with vitamin C via electrospinning.
| Item Type: | Article |
|---|---|
| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Biopolymer; Electrospinning; Oral Dispersible Film (ODF); Polyvinyl alcohol (PVA); Vitamin C; κ-Carrageenan |
| Subjects: | Q Science > QD Chemistry T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General) T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Chemical and Process Engineering Technology |
| Depositing User: | Mr Muhamad Firdaus Janih@Jaini |
| Date Deposited: | 16 Apr 2024 04:23 |
| Last Modified: | 16 Apr 2024 04:23 |
| URI: | http://umpir.ump.edu.my/id/eprint/40408 |
| Download Statistic: | View Download Statistics |
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