Yuandani, . and Ibrahim, Jantan and Emil, Salim and Septama, Abdi Wira and Kamal, Rullah and Nainu, Firzan and Mohd Fadhlizil Fasihi, Mohd Aluwi and Emran, Talhah and Roney, Miah and Nur Aini Khairunnisa, . and Nasution, Halimah Raina and As'ad, Muh. Fadhil and Nur Farisya, Shamsudin and Maryam Aisyah, Abdullah and Rani Marwa, Haya Luthfiyyah and Al Chaira, Diany Mahabbah and Nabila Aulia, . (2024) Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis. Phytotherapy Research, 38 (6). pp. 2931-2961. ISSN 0951-418X. (Published)
|
Pdf
Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites.pdf Download (204kB) | Preview |
|
|
Pdf
Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis.pdf Download (3MB) | Preview |
Abstract
The anti-inflammatory and immunosuppressive activities of plant secondary metabolites are due to their diverse mechanisms of action against multifarious molecular targets such as modulation of the complex immune system associated with rheumatoid arthritis (RA). This review discussed and critically analyzed the potent anti-inflammatory and immunosuppressive effects of several phytochemicals and their underlying mechanisms in association with RA in experimental studies, including preliminary clinical studies of some of them. A wide range of phytochemicals including phenols, flavonoids, chalcones, xanthones, terpenoids, alkaloids, and glycosides have shown significant immunosuppressive and anti-inflammatory activities in experimental RA models and a few have undergone clinical trials for their efficacy and safety in reducing RA symptoms and improve patient outcomes. These phytochemicals have potential as safer alternatives to the existing drugs in the management of RA, which possess a wide range of serious side effects. Sufficient preclinical studies on safety and efficacy of these phytochemicals must be performed prior to proper clinical studies. Further studies are needed to address the barriers that have so far limited their human use before the therapeutic potential of these plant-based chemicals as anti-arthritic agents in the treatment of RA is fully realized.
| Item Type: | Article |
|---|---|
| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Anti-arthritic drugs; Anti-inflammatory; Immune system; Immunosuppressants; Phytochemicals; Rheumatoid arthritis |
| Subjects: | H Social Sciences > HD Industries. Land use. Labor R Medicine > R Medicine (General) T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Industrial Sciences And Technology Institute of Postgraduate Studies |
| Depositing User: | Miss Amelia Binti Hasan |
| Date Deposited: | 28 Jun 2024 05:18 |
| Last Modified: | 28 Jun 2024 05:18 |
| URI: | http://umpir.ump.edu.my/id/eprint/41733 |
| Download Statistic: | View Download Statistics |
Actions (login required)
 |
View Item |