Multiscale Modelling of 3-Dimensional Brain Tissue Using Ideal Capillary Model

Abbas, Shabudin and Mohd Jamil, Mohamed Mokhtarudin and Payne, Stephen J. and Wan Naimah, Wan Ab Naim and Nik Abdullah, Nik Mohamed (2023) Multiscale Modelling of 3-Dimensional Brain Tissue Using Ideal Capillary Model. In: Proceedings of the 2nd Energy Security and Chemical Engineering Congress. Lecture Notes in Mechanical Engineering. 2nd Energy Security and Chemical Engineering Congress (ESChE 2021) , 3-5 November 2021 , Universiti Malaysia Pahang (Virtual Conference). pp. 205-221.. ISSN 2195-4356 ISBN 978-981-19-4424-6

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Abstract

This project aims to investigate the effects of capillary size and shape toward the brain tissue poroelastic properties model using asymptotic expansion homogenization (AEH). Applying AEH to the existing poroelastic governing equations (GE) results in a new GE consists of 6 macroscale equations and 4 microscale cell problems. The cell problems are solved on a microstructure geometry of brain tissue with capillary embedded to obtain effective parametric tensors, namely the capillary and interstitial hydraulic conductivity (K and G ), capillary and interstitial homogenous Biot’s coefficient (αc and αt ), Young’s modulus (E) and Poisson’s ratio (v). By varying the tortuosity, the percentage difference of K is 97.98%, shows that it is highly affected by tortuosity. The percentage difference of G is 0.25% implying that tortuosity insignificantly affecting G. Meanwhile, αc and αt decreases and increases with tortuosity, respectively. The percentage difference of E and v are 0.14% and 0.03% respectively, implying that both parameters does not affected by tortuosity. Besides, K is exponentially increases with the increase of radius. On the other hand, G decreases as the radius increases. Meanwhile αc and αt increases and decreases, respectively as radius increases. The percentage differences of E and v are 18.26% and 14.55% respectively, suggesting that they are significantly affected by the radius. In conclusion, capillary shape and size have significant impact on the simulation of human brain. Thus, both characteristics should be precisely emphasized in the development of the geometry so that accurate parameters can be obtained to solve macroscale equations in future.

Item Type:	Conference or Workshop Item (Paper)
Additional Information:	Indexed by Scopus
Uncontrolled Keywords:	Asymptotic expansion homogenization; Ideal capillary model; Ischaemic stroke; Macroscale equations; Microscale cell problems
Subjects:	T Technology > TJ Mechanical engineering and machinery T Technology > TL Motor vehicles. Aeronautics. Astronautics
Faculty/Division:	Institute of Postgraduate Studies College of Engineering Faculty of Mechanical and Automotive Engineering Technology
Depositing User:	Miss Amelia Binti Hasan
Date Deposited:	02 Jul 2024 08:12
Last Modified:	02 Jul 2024 08:12
URI:	http://umpir.ump.edu.my/id/eprint/41780
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