Eco-friendly and efficient extraction of phenolic compounds from Commiphora gileadensis bark using microwave-assisted extraction

Aiman A., Mokaizh and Nour, Abdurahman Hamid and Ali, Gomaa A.M. and Ukaegbu, Chinonso Ishmael and Hawege, Emsalem Faraj (2024) Eco-friendly and efficient extraction of phenolic compounds from Commiphora gileadensis bark using microwave-assisted extraction. Journal of Industrial and Engineering Chemistry. pp. 1-8. ISSN 1226-086X. (In Press / Online First) (In Press / Online First)

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DOI/Official URL: https://doi.org/10.1016/j.jiec.2024.07.038

Abstract

Commiphora gileadensis (C. gileadensis) is a medicinal plant with a variety of biological activity; its bark has several therapeutic potentials, including the treatment of wounds, inflammatory diseases, and treating bacterial infections. This study utilized microwave-assisted extraction (MAE) to optimize the recovery and phenolic components of the ethanolic extracts of C. gileadensis bark. Different MAE process parameters (microwave power, irradiation time, sample/solvent ratio, extraction temperature, and solvent (ethanol) concentration) were studied for their impacts on the extraction process using One-Factor-At-a-Time (OFAT) method. The extracts were further characterized for the presence of different phytochemicals using Gas Chromatography-Mass Spectroscopy (FC-MS) and Fourier Transform Infrared Spectroscopy (FTIR) analyses. The experimental findings revealed that the maximum extraction yield, total phenolic content (TPC), and total flavonoid content (TFC) of the ethanolic extract of the of C. gileadensis bark using MAE process were 39.40 ± 0.47 w/w%, 166.41 ± 3.97 mg GAE/g d.w., and 52.83 ± 2.95 mg QE/g d.w., respectively. Furthermore, 30 phenolic constituents were discovered in the extract of C. gileadensis bark for the first time, and these compounds showed good in vitro antioxidant activity. Hence, MAE is a suitable technique for efficient and green extraction of different groups of phytochemicals of pharmaceutical importance from the bark of C. gileadensis.

Item Type:	Article
Additional Information:	Indexed by Scopus
Uncontrolled Keywords:	C. gileadensis bark; Gas chromatography-mass spectroscopy; Microwave-assisted extraction; One-Factor-At-a-Time; Phytochemicals
Subjects:	T Technology > TP Chemical technology
Faculty/Division:	Institute of Postgraduate Studies Faculty of Chemical and Process Engineering Technology
Depositing User:	Miss Amelia Binti Hasan
Date Deposited:	14 Aug 2024 08:38
Last Modified:	14 Aug 2024 08:38
URI:	http://umpir.ump.edu.my/id/eprint/42360
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