Biological evaluation of folic acid functionalized nano‐zeolitic imidazolate framework‐8 for cancer therapy

Lai, Xie Yong and Muhamad Ibrahim, Abdul Malek and Azren Aida, Asmawi and Rosniza, Razali and Afiq, Azil and Nur Aininie, Yusoh and Nurul Akmarina, Mohd Abdul Kamal (2024) Biological evaluation of folic acid functionalized nano‐zeolitic imidazolate framework‐8 for cancer therapy. Colloid and Polymer Science. pp. 1-14. ISSN 0303-402X (Print); 1435-1536 (Online). (In Press / Online First) (In Press / Online First)

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Abstract

Conventional chemotherapy often results in toxicity to normal cells and hampers cancer treatment efficacy. Cancer targeting via surface-functionalized nanocarrier offers an excellent opportunity for tackling this unwanted issue. However, a comprehensive understanding of its toxicity and safety in biological entities remains limited. In this study, we report the cancer-selectivity of surface-functionalized nano-zeolitic imidazolate framework-8 (FA@nZIF-8) and its safety characteristics in small organisms including zebrafish embryos and brine shrimp. The FA@nZIF-8 exhibited higher selectivity (3.95) towards cancer cells (MCF7) compared to pure nZIF-8. Moreover, this functionalized nano-ZIF-8 not only enhanced permeability performance but also appeared to be a significant survivability advantage, 80% (P < 0.001) with a higher survival rate compared with pure nZIF-8 at the 96-h mark. No scoliosis appeared in healthy zebrafish embryos for both nanoparticle systems. Monitoring brine shrimps showed minimal toxicity induction at a certain level of concentration. This study suggests that surface-functionalized FA@nZIF-8, with its cancer-selective behavior and promising safety characteristics, has bright potential for further exploration in cancer therapy.

Item Type:	Article
Uncontrolled Keywords:	Cancer; Selectivity; Zebrafsh embryos; Brine shrimps; ZIF-8
Subjects:	R Medicine > RC Internal medicine T Technology > TP Chemical technology
Faculty/Division:	Institute of Postgraduate Studies Faculty of Chemical and Process Engineering Technology
Depositing User:	Mrs Norsaini Abdul Samat
Date Deposited:	17 Dec 2024 04:41
Last Modified:	17 Dec 2024 06:25
URI:	http://umpir.ump.edu.my/id/eprint/43163
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