Kadam, Uttam D. and Pandav, Rajkumar S. and Arde, Satyanarayan M. and Hossain, Md Sanower and Dinesh, Ayyar and Radhakrishnan, Kothalam and Manikandan, Ayyar and Patil, Rajendra P. and Shirke, Bajirao S. (2025) Green synthesis of benzimidazole scaffolds using copper-substituted zinc aluminate in a sol-gel process. Journal of the Indian Chemical Society, 102 (101494). pp. 1-11. ISSN 0019-4522. (Published)
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Abstract
Benzimidazole is a favored scaffold in the field of heterocyclic chemistry because of its diverse range of biological and pharmacological characteristics. As a result, synthetic organic chemistry has seen a sharp increase in interest in developing environmentally friendly synthesis methods for benzimidazole derivatives. Here, we present a novel technique that uses magnetic nanoparticles of copper-substituted zinc aluminate to efficiently catalyze the production of benzimidazole derivatives in water at room temperature and pressure. The catalyst was synthesized via a sol-gel auto-combustion method. The produced copper-substituted zinc aluminate magnetic nanoparticles were thoroughly characterized utilizing a range of spectroscopic methods. The TEM analysis revealed that the catalyst's average grain size was around 50 nm. We are aware that the chemical composition closely resembles the predicted stoichiometry determined from the reactant solutions because of electron density-functional theory elemental analysis. With ferrimagnetic and nanocrystalline properties, the catalyst was highly recyclable and could sustain up to five consecutive reaction cycles before exhibiting a little decrease in activity. The ability of the synthesized material to promote reactions between a range of aldehydes and ortho-phenylenediamine, producing benzimidazole derivatives in moderate to good yields, demonstrated its catalytic effectiveness. Also, this work demonstrates how magnetic nanoparticles may be used in eco-friendly synthetic procedures to produce benzimidazoles by acting as a reusable and effective catalyst.
| Item Type: | Article |
|---|---|
| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Ambient conditions; Benzimidazole derivatives; Green synthesis; Heterogeneous catalysis; Magnetic nanomaterials; Reusability; Sol-gel auto-combustion method |
| Subjects: | T Technology > TA Engineering (General). Civil engineering (General) T Technology > TN Mining engineering. Metallurgy |
| Faculty/Division: | Centre for Sustainability of Mineral & Resource Recovery Technology (SMARRT) |
| Depositing User: | Mr Muhamad Firdaus Janih@Jaini |
| Date Deposited: | 20 Feb 2025 05:04 |
| Last Modified: | 20 Feb 2025 05:04 |
| URI: | http://umpir.ump.edu.my/id/eprint/43870 |
| Download Statistic: | View Download Statistics |
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