Khairool Azizul, Mohammad and Syarifah, Abd Rahim and Mohd Rushdi, Abu Bakar (2014) Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-Crystal. In: 2nd International Conference on Global Sustainability and Chemical Engineering (ICDSCE) 2014 , 20-22 August 2014 , Kuala Lumpur. .
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Nucleation_Kinetics_of_Carbamazepine-Saccharin_(CBZ-SAC)_Co-Crystal.PDF - Published Version Restricted to Repository staff only Download (552kB) |
Abstract
In this study the effect of the heating/cooling rate of various CBZ-SAC mixture in ethanol was investigated in order to deduce the metastable zone width (MSZW) and the nucleation order. Nivlt' s equation involving the maximum temperature difference ATm between dissolution and crystallization temperatures of CBZ-SAC co-crystals with the heating/cooling rate r was applied for the study of nucleation kinetics by the polythermal method. A step towards the determination of dissolution temperature of the crystals has been improved. The results showed that dissolution temperature for CBZ-SAC co-crystal mixture increased with the increase in heating rate, CBZ-concentration and the ratio of SAC to CBZ in ethanol solution. The analysis revealed that a nucleation order for CBZ-SAC co-crystals increases with the SAC to CBZ ratio and is in the range of 1.58 to 6.31.
| Item Type: | Conference or Workshop Item (Speech) |
|---|---|
| Uncontrolled Keywords: | Rystallization; cCo-crystal; Carbamazepine; Metastable zone width; Nucleation kinetics |
| Subjects: | T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Chemical & Natural Resources Engineering |
| Depositing User: | Ms. Hazima Anuar |
| Date Deposited: | 29 Oct 2014 07:07 |
| Last Modified: | 03 Mar 2015 09:32 |
| URI: | http://umpir.ump.edu.my/id/eprint/6744 |
| Download Statistic: | View Download Statistics |
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