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Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-Crystal

Khairool Azizul, Mohammad and Syarifah, Abd Rahim and Mohd Rushdi, Abu Bakar (2014) Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-Crystal. In: 2nd International Conference on Global Sustainability and Chemical Engineering (ICDSCE) 2014, 20-22 August 2014 , Kuala Lumpur. .

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Abstract

In this study the effect of the heating/cooling rate of various CBZ-SAC mixture in ethanol was investigated in order to deduce the metastable zone width (MSZW) and the nucleation order. Nivlt' s equation involving the maximum temperature difference ATm between dissolution and crystallization temperatures of CBZ-SAC co-crystals with the heating/cooling rate r was applied for the study of nucleation kinetics by the polythermal method. A step towards the determination of dissolution temperature of the crystals has been improved. The results showed that dissolution temperature for CBZ-SAC co-crystal mixture increased with the increase in heating rate, CBZ-concentration and the ratio of SAC to CBZ in ethanol solution. The analysis revealed that a nucleation order for CBZ-SAC co-crystals increases with the SAC to CBZ ratio and is in the range of 1.58 to 6.31.

Item Type: Conference or Workshop Item (Speech)
Uncontrolled Keywords: Rystallization; cCo-crystal; Carbamazepine; Metastable zone width; Nucleation kinetics
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Chemical & Natural Resources Engineering
Depositing User: Ms. Hazima Anuar
Date Deposited: 29 Oct 2014 07:07
Last Modified: 03 Mar 2015 09:32
URI: http://umpir.ump.edu.my/id/eprint/6744
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