M. Rafiqul, Islam and Mimi Sakinah, A. M. and Zularisam, A. W. (2014) Inhibition By Toxic Compounds In The Hemicellulosic Hydrolysates On The Activity Of Xylose Reductase From Candida Tropicalis. Biotechnology Letters, 37 (1). pp. 191-196. ISSN 1573-6776. (Published)
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Abstract
Xylose reductase (XR) is an oxidoreductase having potential applications in the production of various specialty products, mainly xylitol. It is important to screen for compounds that can decrease XR activity and consequently can decrease xylitol production. We have identified the byproducts in the hemicellulosic hydrolysate that inhibit XR from Candida tropicalis and measured their effects. XR inhibitory activities of byproducts, glucose, acetic acid, arabinose, lignin-degradation products (LDPs), furfural and hydroxymethylfurfural (HMF), were evaluated by measuring the MIC and IC50 values. XR activity was 11.2 U/ml. Acetic acid, LDPs, furfural and HMF significantly inhibited XR with IC50 values of 11, 6.4, 2.3 and 0.4 g/l, respectively. This is the first report on the inhibitory activities of several byproducts for XR.
| Item Type: | Article |
|---|---|
| Additional Information: | Indexed in Scopus |
| Subjects: | T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Chemical & Natural Resources Engineering |
| Depositing User: | Prof. Dr. Mimi Sakinah Abd Munaim |
| Date Deposited: | 30 Dec 2014 08:08 |
| Last Modified: | 29 Nov 2018 07:26 |
| URI: | http://umpir.ump.edu.my/id/eprint/7993 |
| Download Statistic: | View Download Statistics |
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