E N, Engku Mat Nasir and F, Ab Rahman and Syarifah, Abd Rahim and R Z, Edros and N., Anuar (2020) Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation. IOP Conf. Series: Materials Science and Engineering, 736 (022109). pp. 1-7. ISSN 1757-899X. (Published)
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Abstract
Abstract. The crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation is presented.The particle size distribution study of CBZ-SAC co-crystals revealed that the multimodal with broad PSD was found for CBZ concentration of 19.14 mg/ml. Meanwhile, the unimodal with broad PSD were observed at CBZ concentration of 17.01 mg/ml and 17.96 mg/ Crystal characterisation using differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier transform infrared (FTIR) and optical microscopy confirm the solid formed is CBZ-SAC co-crystal Form I with plate-like crystal morphology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Crystallisation parameters effect: particle size distribution (PSD): carbamazepine-saccharin (CBZ-SAC) co-crystals: crystallisation |
| Subjects: | T Technology > TP Chemical technology |
| Faculty/Division: | Institute of Postgraduate Studies Faculty of Chemical and Process Engineering Technology |
| Depositing User: | Miss. Ratna Wilis Haryati Mustapa |
| Date Deposited: | 27 Jan 2021 06:41 |
| Last Modified: | 27 Jan 2021 06:41 |
| URI: | http://umpir.ump.edu.my/id/eprint/30578 |
| Download Statistic: | View Download Statistics |
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