Aptamer-based rapid diagnosis for point-of-care application

Futane, Abhishek and Narayanamurthy, Vigneswaran and Jadhav, Pramod and Srinivasan, Arthi (2023) Aptamer-based rapid diagnosis for point-of-care application. Microfluidics and Nanofluidics, 27 (15). pp. 1-33. ISSN 1613-4982. (Published)

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Abstract

Aptasensors have attracted considerable interest and widespread application in point-of-care testing worldwide. One of the biggest challenges of a point-of-care (POC) is the reduction of treatment time compared to central facilities that diagnose and monitor the applications. Over the past decades, biosensors have been introduced that offer more reliable, cost-effective, and accurate detection methods. Aptamer-based biosensors have unprecedented advantages over biosensors that use natural receptors such as antibodies and enzymes. In the current epidemic, point-of-care testing (POCT) is advantageous because it is easy to use, more accessible, faster to detect, and has high accuracy and sensitivity, reducing the burden of testing on healthcare systems. POCT is beneficial for daily epidemic control as well as early detection and treatment. This review provides detailed information on the various design strategies and virus detection methods using aptamer-based sensors. In addition, we discussed the importance of different aptamers and their detection principles. Aptasensors with higher sensitivity, specificity, and flexibility are critically discussed to establish simple, cost-effective, and rapid detection methods. POC-based aptasensors’ diagnostic applications are classified and summarised based on infectious and infectious diseases. Finally, the design factors to be considered are outlined to meet the future of rapid POC-based sensors.

Item Type:	Article
Additional Information:	Indexed by Scopus
Uncontrolled Keywords:	Aptamer; Biosensors; Diagnosis; Point of care
Subjects:	Q Science > QD Chemistry T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General) T Technology > TP Chemical technology
Faculty/Division:	Institute of Postgraduate Studies College of Engineering Faculty of Chemical and Process Engineering Technology Faculty of Civil Engineering Technology
Depositing User:	Mr Muhamad Firdaus Janih@Jaini
Date Deposited:	31 Oct 2023 07:34
Last Modified:	31 Oct 2023 07:34
URI:	http://umpir.ump.edu.my/id/eprint/38694
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