Sardjono, Ratnaningsih Eko and Gunawan, Ramdhan and Kadarohman, Asep and Erdiwansyah, E. and Rizalman, Mamat and Melati, Khairuddean (2024) Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug. Case Studies in Chemical and Environmental Engineering, 9 (100562). pp. 1-9. ISSN 2666-0164. (Published)
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Abstract
Parkinson's disease is a neurodegenerative disease caused by low dopamine levels in the brain. This study aims to obtain the optimum condition for M. pruriens extract nanoencapsulation in nano starch (NS-MPn) and nanostarch-maltodextrin (NS-MD-MPn), nanocapsules characteristics, and their potential as anti-Parkinsonian drug. The nanoencapsulation process was carried out by ultrasonic method. FTIR, SEM, and TEM carried out the characterization of NS-MPn and NS-MD-MPn nanocapsules. Encapsulation efficiency was evaluated by UV-Vis spectroscopy. SEM and TEM characterization NS-MPn and NS-MD-MPn nanocapsules have non-spherical surface morphology, spherical in shape 234.98 and 90.85 nm, respectively. NS-MPn have 21.35% encapsulation efficiency, meanwhile, NS-MD-MPn has 30.02%.
| Item Type: | Article |
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| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Anti–Parkinson; Mucuna pruriens; Nanoencapsulation; Nanostarch; Parkinson's disease |
| Subjects: | T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General) T Technology > TJ Mechanical engineering and machinery T Technology > TL Motor vehicles. Aeronautics. Astronautics |
| Faculty/Division: | Institute of Postgraduate Studies Faculty of Mechanical and Automotive Engineering Technology |
| Depositing User: | Mr Muhamad Firdaus Janih@Jaini |
| Date Deposited: | 18 Jan 2024 06:38 |
| Last Modified: | 18 Jan 2024 06:38 |
| URI: | http://umpir.ump.edu.my/id/eprint/40087 |
| Download Statistic: | View Download Statistics |
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