Khairool Azizul, Mohammad and Wei, Michelle Ho Siaw and Engku Nuraishah Huda, Engku Zainudin and Syarifah, Abd Rahim (2024) Impact of the SAC : CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization. Journal of Thermal Analysis and Calorimetry. pp. 1-13. ISSN 1388-6150. (In Press / Online First) (In Press / Online First)
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Abstract
Carbamazepine-saccharin (CBZ-SAC) co-crystal is one of the most studied co-crystals to date. It is proven to be polymorphic, consisting of Form I (plate-like shape) and Form II (needle-like shape), which is rarely reported by researchers. The present study aimed to study the effect of SAC:CBZ ratio on the polymorphic transformation and morphology of CBZ-SAC co-crystals using ice bath fast cooling crystallization. A series of CBZ-SAC co-crystals were produced from different SAC:CBZ mol ratios (1:1, 2:1, 3:1, 4:1, 5:1, 6:1) and were compared in terms of their crystal form and morphology under microscope. The polymorphic changes were also studied from the CBZ-SAC suspension during co-crystallization process. The polymorphs of CBZ-SAC co-crystals were identified using PXRD, DSC, ATR-FTIR. The results showed that at lower ratio (1:1, 2:1, 3:1), only plate-like shaped crystals (Form I) was present. For higher mol ratio (4:1, 5:1, 6:1), mixture of Form I and II of CBZ-SAC co-crystals were observed and further confirmed by DSC and ATR-FTIR. The nucleation process showed that Form II could convert to Form I when varying the SAC:CBZ ratio. Hence, it is proven that SAC:CBZ mol ratio can affect the polymorphic transformation and morphology of CBZ-SAC co-crystals. Nonetheless, other parameters should be used to further study the formation of CBZ-SAC co-crystals since pure CBZ-SAC Form II co-crystals were not obtained in this study.
| Item Type: | Article |
|---|---|
| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Carbamazepine; Co-crystals; Fast cooling; Morphology; Polymorphic; Saccharin |
| Subjects: | Q Science > QD Chemistry T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General) T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Chemical and Process Engineering Technology |
| Depositing User: | Mr Muhamad Firdaus Janih@Jaini |
| Date Deposited: | 30 Sep 2024 04:50 |
| Last Modified: | 30 Sep 2024 04:50 |
| URI: | http://umpir.ump.edu.my/id/eprint/42128 |
| Download Statistic: | View Download Statistics |
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