Use of microfluidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs

Shahabipour, Fahimeh and Aldhaher, Abdullah and Doseff, Andrea I. and Alavian, Seyed Ehsan and Elnour, Adam Hassan Mohammed and Ashammakhi, Nureddin (2023) Use of microfluidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs. In: Phytopharmaceuticals and Herbal Drugs : Prospects and Safety Issues in the Delivery of Natural Products. Elsevier, Amsterdam, Netherlands, pp. 323-339. ISBN 978-032399125-4, 978-032399369-2

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Abstract

Natural products (NPs) and their derivatives constitute an important source of bioactive pharmaceutical compounds. Due to the increasing interest in NPs, finding new approaches for rapid screening of novel chemistries and evaluating their potential toxicity is of paramount significance. The extensive repertoire of NPs and derivatives and their presence as complex mixtures presents challenges at multiple levels, including the screening for the bioactive components and real-time detection of drugs effects. Recent advances in microfluidic approaches such as organ-on-a-chip, Herbochip, microfluidic biochip, and multiorgan-on-chip have been developed to facilitate the real-time detection of drug effects on cancer cells. Microfluidic devices enable high throughput and reliable detection of drug cytotoxicity in cell-free systems. Here, we review different microfluidic devices, such as Herbochip and organ-on-chip. The impact of these devices is to identify active components from herbal extraction, the potential of helping to understand the mechanisms of botanical drugs, and determining cytotoxicity of new lead compounds. We also highlight the influence of microfluidic devices, such as organ-on-chip and Herbochip, in translating NP activities into the development of drugs toward precision medicine.

Item Type:	Book Chapter
Additional Information:	Indexed by Scopus
Uncontrolled Keywords:	Herbal drugs; Herbochip; Natural products; Organ-on-a-chip; Phytochemical
Subjects:	T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General) T Technology > TP Chemical technology
Faculty/Division:	Institute of Postgraduate Studies Faculty of Chemical and Process Engineering Technology
Depositing User:	Mr Muhamad Firdaus Janih@Jaini
Date Deposited:	02 Dec 2024 01:14
Last Modified:	02 Dec 2024 01:14
URI:	http://umpir.ump.edu.my/id/eprint/42517
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